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Welcome

St. George’s, University of London (SGUL)’ Institute of  Infection and Immunity has an annual fundraising event, called Jennerosity, to support local charities. This year, Jennerosity has selected to support World Without TB.  Funds raised will be devoted to the SGUL INTERTB Consortium which carries out international research to reduce treatment duration for tuberculosis. WWTB thanks SGUL for their support!

 

Tuberculosis (TB) is one of the major preventable causes of sickness and death in many countries of the world. While most common in developing countries, it is also of concern as an emerging disease of the developed world. TB, along with malaria and Human Immunodeficiency (HIV) are diseases largely affecting people living in extreme poverty.

World Without Tuberculosis (WWTB) is a London, UK based registered charity. Our mission is the global eradication of tuberculosis through the identification of safe and effective treatment regimens of very short durations.

The United Nations Millennium Development Goals objectives for tuberculosis are to have halted and begun to reverse the incidence of tuberculosis by 2015 and to have eliminated tuberculosis by 2050.

The World Health Organisation's Global Tuberculosis Report, 2015 has just been published which states that in 2014, TB killed 1.5 million people (1.1 million HIV-negative and 0.4 million HIV-positive). The toll comprised 890 000 men, 480 000 women and 140 000 children. It goes on to state that TB now ranks alongside HIV as a leading cause of death worldwide.

The estimated number of new cases in 2014 is 9.6 million. In 2000 the estimated number of new cases was 8.74 million.

Small wonder that on 20 November 2015 The Stop TB Partnership published “The world is losing its battle with tuberculosis (TB), which is now the biggest infectious killer globally, causing 1.5 million deaths every year. Without a clear investment plan and a complete overhaul in how this disease is tackled, TB is unlikely to be eliminated until the end of the 22nd century”.

The current incidence and prevalence of TB is severely straining the capacity of some National Tuberculosis Control Programmes to successfully administer the World Health Organisation (WHO) recommended standard 6-month treatment regimen. The estimated development of any new anti-tuberculosis drugs, from discovery to marketing, is approximately 20 years at a cost of $5billion. By testing different combinations of drugs that are already in use, WWTB believe that we can cut that development time by 10 years and at a far lower cost. This will provide a realistic and affordable Tuberculosis treatment regime for many countries in the world.

World Without Tuberculosis, is devoted to the rapid eradication of TB, by carrying out small scale clinical trials using drugs currently licensed and given for the treatment of the disease.

Trials of these drugs in new combinations could cut the length of time patients have to take their medicine by a third, and possibly even by half.

In the absence of an effective vaccine, a substantial reduction of treatment duration offers the only hope of reducing the mortality from tuberculosis.

Although, the first objective of the Millennium Development Goals has not been met, if in the next 5 years treatment duration for tuberculosis can be substantially reduced, there is a real possibility that the second goal of tuberculosis elimination by 2050 can be met.

World Without Tuberculosis is a CHARITY REGISTERED WITH THE UNITED KINGDOM CHARITIES COMMISSION, REGISTRATION NUMBER 1118938